Cancer (co-treatment)
Hyperbaric Oxygen Therapy (HBOT) can serve as a powerful adjunctive treatment supporting Cancer patients and their recovery. Late effects of radiation therapy (LERT) encompass one-third of HBOT treatments in the US. Radiation therapy is extremely effective at killing the malignancy and curing cancer, but does come with after effects. Hyperbaric is extremely effective at restoring function to tissue post-radiation due to its ability to reverse hypoxia, hypovascularity, and hypocellularity. HBOT enhances chemotherapeutic effects by reducing tissue hypoxia that contributes to the radioresistance of many tumors and may also reduce their sensitivity to some chemotherapeutic agents.
HBOT reverses cancer’s hypoxic microenvironment and improves neoplastic tissue oxygenation, inhibits HIF-1α activity, enhances chemosensitization, improves tumor-inhibitory effects, radiation sensitization of solid tumors, increases anticancer therapy effectiveness, stimulates angiogenesis and reverses injured tissue hypovascularity, and improves overall cellular health.
HBOT is not just effective post-treatment, but also pre-treatment, creating healthier tissue that is prepared to sustain high radiation. Marx protocol is an example widely used to improve outcomes.
Hypoxia emerges as an important factor involved in the tumor growth and aggressiveness, metabolic reprogramming, angiogenesis, resistance to cell death, immunosuppression, inflammation, and glial-to-mesenchymal transition of cancer cells. Hyperbaric oxygen therapy (HBOT) may increase anticancer therapy sensitivity by increasing oxygen tension within the hypoxic regions of the neoplastic tissue. HBOT does not stimulate pre-growth effect on cancer cells.
Previous data have investigated HBOT in combination with cytostatic compounds, with an improvement of neoplastic tissue oxygenation, inhibition of HIF-1α activity, and a significant reduction in the proliferation of GBM cells, one of the most common and aggressive malignant brain tumors in adults. GBM’s hypoxic microenvironment has been shown to be highly associated with aggressive biology and resistance to RT and CT. Hyperbaric oxygen therapy (HBOT) may increase anticancer therapy sensitivity by increasing oxygen tension within the hypoxic regions of the neoplastic tissue.
Hyperbaric oxygen therapy and cancer—a review https://pmc.ncbi.nlm.nih.gov/articles/PMC3510426/
A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities https://pmc.ncbi.nlm.nih.gov/articles/PMC8465921/
Hyperbaric Oxygen Therapy as a Complementary Treatment in Glioblastoma—A Scoping Review https://pmc.ncbi.nlm.nih.gov/articles/PMC9283648/
Hyperbaric oxygen: does it promote growth or recurrence of malignancy? https://www.ncbi.nlm.nih.gov/pubmed/12841604
Hyperbaric oxygen therapy for malignancy: a review https://www.ncbi.nlm.nih.gov/pubmed/17102915
Radiation Therapy Plus Hyperbaric Oxygen in Treating Patients With Newly Diagnosed Glioblastoma Multiforme https://clinicaltrials.gov/study/NCT00006460n
A review of the Marx protocols: prevention and management of osteoradionecrosis by combining surgery and hyperbaric oxygen therapy https://pubmed.ncbi.nlm.nih.gov/10023268/
Hyperbaric Treatment of Delayed Radiation Injury https://www.ncbi.nlm.nih.gov/books/NBK470447/
Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol https://isom.ca/article/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol/
Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127407
The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522
Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model https://www.sciencedirect.com/science/article/pii/S0022522302733370
CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen – changes with oxygen dosage https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037447/
Lung metastatic load limitation with hyperbaric oxygen https://www.ncbi.nlm.nih.gov/pubmed/17520859
Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma https://www.ncbi.nlm.nih.gov/pubmed/19787219
Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions https://www.ncbi.nlm.nih.gov/pubmed/20562529
Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy: a preliminary report https://www.ncbi.nlm.nih.gov/pubmed/21287528
The use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report https://bmcurol.biomedcentral.com/articles/10.1186/s12894-020-00767-3
